Houston Police say it happened just before 11 a.m. in the 2900 block of Napoleon.
Officers arrived within 5 minutes and found the male victim dead behind one of the houses.
SkyFOX was over the scene and captured a white luxury vehicle with multiple bullet holes on the passenger-side window.
Witnesses tell police that a white F250 extended cab pickup truck with three occupants pulled up, and the passenger got out and fired multiple shots into the victim's vehicle.
The victim got out of his car to run away and as he was being helped by family, the suspects drove away.
Houston Police say they do not know the identity of the suspects, but witnesses tell them that they were three Black men wearing lime green work vests or traffic reflector vests.
Police believe organized gang activity is involved in the incident.